As part of the general style overhaul, might it be a good idea to look into a better default font? The default matplotlib font, Bitstream Vera, only has a very limited set of characters. In additional to lacking support for non-Latin alphabets, it also lacks a lot of characters that are important in scientific and numerical work, such as greek letters and mathematical symbols (for example you can't do "μs" in the default font if you want to abbreviate "microsecond"). This seems to be a pretty major omission.

If we want to keep things pretty similar, the DejaVu font family is mostly the same as Bitsream, but has a lot more characters. Further, it is under a similarly liberal license.

If you want to search further afield, there are also a lot of newer fonts under liberal licenses that could be used.