@@ -118,8 +118,10 @@ export function withEventReplay(): Provider[] {
       {
         provide: APP_BOOTSTRAP_LISTENER,
         useFactory: () => {
+          const appId = inject(APP_ID);
           const injector = inject(Injector);
           const appRef = inject(ApplicationRef);
+
           return () => {
             // We have to check for the appRef here due to the possibility of multiple apps
             // being present on the same page. We only want to enable event replay for the
@@ -129,7 +131,17 @@ export function withEventReplay(): Provider[] {
             }
 
             appsWithEventReplay.add(appRef);
-            appRef.onDestroy(() => appsWithEventReplay.delete(appRef));
+
+            appRef.onDestroy(() => {
+              appsWithEventReplay.delete(appRef);
+              // Ensure that we're always safe calling this in the browser.
+              if (typeof ngServerMode !== 'undefined' && !ngServerMode) {
+                // `_ejsa` should be deleted when the app is destroyed, ensuring that
+                // no elements are still captured in the global list and are not prevented
+                // from being garbage collected.
+                clearAppScopedEarlyEventContract(appId);
+              }
+            });
 
             // Kick off event replay logic once hydration for the initial part
             // of the application is completed. This timing is similar to the unclaimed
 
@@ -6,7 +6,7 @@
  * found in the LICENSE file at https://angular.dev/license
  */
 
-import {Component, destroyPlatform, ErrorHandler, PLATFORM_ID, Type} from '@angular/core';
+import {APP_ID, Component, destroyPlatform, ErrorHandler, PLATFORM_ID, Type} from '@angular/core';
 import {
   withEventReplay,
   bootstrapApplication,
@@ -142,6 +142,40 @@ describe('event replay', () => {
     expect(onClickSpy).toHaveBeenCalled();
   });
 
+  it('should cleanup `window._ejsas[appId]` once app is destroyed', async () => {
+    @Component({
+      selector: 'app',
+      standalone: true,
+      template: `
+        <button id="btn" (click)="onClick()"></button>
+      `,
+    })
+    class AppComponent {
+      onClick() {}
+    }
+
+    const html = await ssr(AppComponent);
+    const ssrContents = getAppContents(html);
+    const doc = getDocument();
+
+    prepareEnvironment(doc, ssrContents);
+    resetTViewsFor(AppComponent);
+
+    const btn = doc.getElementById('btn')!;
+    btn.click();
+
+    const appRef = await hydrate(doc, AppComponent, {
+      hydrationFeatures: () => [withEventReplay()],
+    });
+    appRef.tick();
+    const appId = appRef.injector.get(APP_ID);
+
+    appRef.destroy();
+    // This ensure that `_ejsas` for the current application is cleaned up
+    // once the application is destroyed.
+    expect(window._ejsas![appId]).toBeUndefined();
+  });
+
   it('should route to the appropriate component with content projection', async () => {
     const outerOnClickSpy = jasmine.createSpy();
     const innerOnClickSpy = jasmine.createSpy();